Ketogenic diet is a high
fat, adequate protein and low carbohydrate diet that has been shown
to be effective in reducing seizure frequency in some children.
Though the diet and its effectiveness in seizure disorder was known
as early as the Middle Ages, it was soon overshadowed by the introduction
of anticonvulsants in the 1930s. Interest in ketogenic diet was
rekindled in 1994, when a child with difficult- to- control seizures
was successfully treated on the diet. Recent studies have shown
that approximately half of children with seizures that don't respond
to medications have a 50% or greater decrease in seizures
The diet provides
4 grams of fat for every 1 gram of protein and carbohydrate; this
is carefully calculated and individualized for every child. People
on a ketogenic diet have to eat mostly fatty foods, such as butter,
cream, and peanut butter. Foods such as bread, pasta, fruits, and
vegetables have to be severely limited, and the person's total calories
and fluids are also restricted. The diet is supplemented with vitamins
and calcium..
Te exact nature of how the diet works remains a mystery. The diet
is designed to simulate the metabolic changes associated with starvation.
During starvation, the body first utilizes its store of glucose
and glycogen and then begins to burn the stored body fat. However,
when there is not sufficient glucose available, as happens during
starvation, the fats cannot be completely burned and ketone bodies
are left, as the residue of incompletely burned fat. Ketogenic diets
supply fats from outside, but limits the availability of glucose,
hence ketone bodies build up. It is the high level of these ketones
that appear to suppress seizures..
The
diet is usually recommended for difficult-to-treat seizures, i.e.,
individuals who have at least two seizures per week despite two
appropriate trials of anticonvulsant medications. The diet is usually
prescribed to children between the age groups of 1-16 years, efficacy
in adults and children below the age of one year has not been ascertained
The ketogenic diet is not a 'do-it-yourself' diet. It is a strict
dietary regimen that is specifically designed for each individual
child. The diet is initiated in a hospital and begins with a period
of starvation; subsequent the dietary regimen is instituted. Strict
adherence to the dietary protocol is important to avoid breakthrough
seizures. Urinary levels of ketones are monitored; according to
current standards urinary ketone levels have to be maintained at
4+. The diet can cause side-effects, which include dehydration,
constipation, vomiting, kidney stones, behavior changes and slowed
growth rates. If successful, the diet should be continued for a
minimum of two years; recurrence of seizures associated with discontinuation
of the diet can be controlled by reintroducing the dietary regimen.
The diet, if adequately complied with, has been shown to be effective
in not only medication-resistant seizures, but has also been shown
to decrease the need for medications, i.e., enables a seizure-free
and medication-free life.
Key points:
Ketogenic diet is effective and can be tried in children who are
not responding adequately to anticonvulsants..
One-third children might
not show any response to the diet also.
The diet should be initiated
under medical care.
The dietary regimen should
be strictly adhered to and no change should be made without medical
supervision.